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Table 2 Brief summary of the different classes of phosphate binders

From: Considerations about the effectiveness and cost effectiveness of therapies in the treatment of hyperphosphataemia

Property OsvaRen® Renagel®/Renvela® e.g. CC-Nefro®,
Dreisacarb®
Active compound class Phosphate binder with reduced calcium content and proportion of magnesium (combination preparation) Calcium-free phosphate binder Calcium-containing phosphate binder
Active compound Calcium acetate/magnesium carbonate Sevelamer hydrochloride/
Sevelamer carbonate
Calcium acetate
Calcium carbonate
Licensed October 2007 April 2001/June 2009 Since the late 1980s
Brand name OsvaRen® film tablets Renagel® 800 mg film tablets Calcium acetate:
Calciumacetat-Nefro®, Calciumacetat Prorenal AM®, Phos-Ex®, amongst others
Calcium carbonate:
CC-Nefro®, Dreisacarb®, Calci-Gry®, amongst others
Manufacturer Fresenius Medical Care Genzyme Corporation Various
Price/Packaging unit (Germany) € 49.75 [23] € 297.29 [23] • Calciumacetat-Nefro®22.68,
• Calciumacetat Prorenal AM® € 18.10,
• Phos-Ex® € 27.69,
• CC-Nefro® € 24.53,
• Dreisacarb® € 24.53,
• Calci-Gry® € 24.57
Dosing
(Film tablets each day depending on the serum phosphate level)
3-10 3-15 • Calciumacetat-Nefro® 9-16,
• Calciumacetat Prorenal AM® 9-16,
• Phos-Ex® 8-16,
• CC-Nefro® 12-18,
• Dreisacarb® 6-12,
• Calci-Gry® 1-2
Price/day (Euro) € 0.83 to € 2.76 € 4.95 to € 24.77 • Calciumacetat-Nefro® € 1.02-1.82,
• Calciumacetat Prorenal AM® € 0.82-1.45,
• Phos-Ex® € 1.11-2.22,
• CC-Nefro® € 1.48-2.21,
• Dreisacarb® € 0.74-1.48,
• Calci-Gry® € 0.25-0.50
Treatment cost/year (Euro) € 300 to € 1,000
on average € 650
€ 1,800 to € 9,000
on average € 5,400
• Calciumacetat-Nefro® € 400-700,
• Calciumacetat Prorenal AM® € 300-500,
• Phos-Ex® € 400-800,
• CC-Nefro® € 500-800,
• Dreisacarb® € 300-500,
• Calci-Gry® € 100-200