From: Methodological considerations in cost of illness studies on Alzheimer disease
 | All studies | Lopez Bastida et al. [13] | Coduras et al. [14] | Rigaud et al. [15] | Kronborg Andersen et al. [16] | Cavallo et al. [17] | Mesterton et al. [18] | Kiencke et al. [19] | Leon et al. [20] | Hay et al. [21] | Rice et al. [22] | Leon et al. [23] | Ostbye et al. [24] | Zencir et al. [25] | Wang et al. [26] | Suh et al. [27] | Beeri et al. [28] | Allegri et al. [29] | ||||||||||||||||||||||||||||||||||||
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 | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No | Yes | P | No |
1 Was a clear definition of the illness given? | 10 | 5 | 2 | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Â | P | Â | Â | P | Â | Yes | Â | Â | Â | Â | No | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â |
2 Were epidemiological sources carefully described? | 13 | 3 | 1 | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â |
3 Were costs sufficiently disaggregated ? | 12 | 0 | 5 | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â |
4 Were activity data sources carefully described? | 15 | 1 | 1 | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â |
5 Were activity data appropriately assessed? | 6 | 9 | 2 | Yes | Â | Â | Â | P | Â | Â | P | Â | Â | P | Â | Â | P | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | Â | No | Â | P | Â | Â | P | Â | Yes | Â | Â | Â | P | Â | Â | P | Â |
6 Were the sources of all cost values analytically described? | 10 | 4 | 3 | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | P | Â | Â | Â | No | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â |
7 Were unit costs appropriately valued? | 7 | 5 | 5 | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | P | Â | Â | P | Â | Yes | Â | Â | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | Â | No | Â | Â | No | Â | Â | No | Yes | Â | Â | Yes | Â | Â | Â | Â | No | Â | P | Â |
8 Were the methods adopted carefully explained? | 11 | 6 | 0 | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | P | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â |
9 Were costs discounted ? | 0 | 2 | 15 | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | P | Â | Â | Â | No | Â | P | Â | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No |
10 Were the major assumptions tested in a sensitivity analysis? | 3 | 0 | 14 | Â | Â | No | Yes | Â | Â | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Yes | Â | Â | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Â | Â | No | Yes | Â | Â | Â | Â | No | Â | Â | No |
11 Was the presentation of study results consistent with the methodology of study? | 13 | 4 | 0 | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â | Yes | Â | Â | Yes | Â | Â | Â | P | Â | Yes | Â | Â |
12 Total score by study | 100 | 39 | 48 | 8 | 1 | 2 | 9 | 1 | 1 | 6 | 2 | 3 | 7 | 2 | 2 | 4 | 4 | 3 | 7 | 2 | 2 | 4 | 4 | 3 | 7 | 1 | 3 | 7 | 2 | 2 | 5 | 4 | 2 | 3 | 4 | 4 | 2 | 2 | 7 | 5 | 3 | 3 | 8 | 1 | 2 | 8 | 1 | 2 | 3 | 3 | 5 | 7 | 2 | 2 |