Table 1 Variables included in the model
Value | |||
|---|---|---|---|
Variable | Average | Minimum | Maximum |
Age (number of residents) | |||
18-64 years | 29,963,795 | ||
≥ 65 years | 7,914,361 | ||
Work status (%) | |||
Employed | 59.88% | ||
Unpaid household work | 8.78% | ||
Other | 31.34% | ||
HAE Prevalence per 100,000 persons | 2.00 | 1.00 | 4.00 |
Number of episodes per year | 6.00 | 3.00 | 9.00 |
Severity (%) | |||
Mild | 35.00% | ||
Moderate | 45.00% | ||
Severe | 20.00% | ||
Episode duration with strategy 1 (hours) | |||
Mild | 15.00 | 13.00 | 18.00 |
Moderate | 10.00 | 8.00 | 12.00 |
Severe | 17.00 | 14.00 | 21.00 |
Reduction of episode duration with strategy 2 (%) | |||
Mild | 50.00% | ||
Moderate | 60.00% | ||
Severe | 70.00% | ||
Episode duration with strategy 2 (hours) | |||
Mild | 7.50 | 6.50 | 9.00 |
Moderate | 4.00 | 3.20 | 4.80 |
Severe | 5.10 | 4.20 | 6.30 |
With strategy 1, a mild episode results in (%) | |||
Hospital emergency room visit | 2.00% | 1.00% | 3.00% |
Primary care emergency room visit | 3.00% | 2.00% | 4.00% |
HAE specialist office visit | 2.00% | 1.00% | 3.00% |
No emergency visit | 93.00% | 96.00% | 90.00% |
With strategy 1, a moderate episode results in (%) | |||
Hospital emergency room visit | 70.00% | 60.00% | 80.00% |
Primary care emergency room visit | 5.00% | 3.00% | 7.00% |
HAE specialist office visit | 10.00% | 7.00% | 12.00% |
No emergency visit | 15.00% | 30.00% | 1.00% |
With strategy 1, a severe episode results in (%) | |||
Hospital emergency room visit | 87.00% | 85.00% | 89.00% |
Primary care emergency room visit | 2.00% | 1.00% | 3.00% |
HAE specialist office visit | 9.00% | 6.00% | 8.00% |
No emergency visit | 2.00% | 8.00% | 0.00% |
With strategy 2, a mild episode results in (%) | |||
Hospital emergency room visit | 0.00% | 0.00% | 0.00% |
Primary care emergency room visit | 0.00% | 0.00% | 0.00% |
HAE specialist office visit | 0.00% | 0.00% | 0.00% |
No emergency visit | 100.00% | 100.00% | 100.00% |
With strategy 2, a moderate episode results in (%) | |||
Hospital emergency room visit | 10.00% | 7.00% | 12.00% |
Primary care emergency room visit | 1.00% | 0.00% | 2.00% |
HAE specialist office visit | 3.00% | 1.00% | 5.00% |
No emergency visit | 86.00% | 92.00% | 81.00% |
With strategy 2, a severe episode results in (%) | |||
Hospital emergency room visit | 15.00% | 12.00% | 18.00% |
Primary care emergency room visit | 1.00% | 0.00% | 2.00% |
HAE specialist office visit | 4.00% | 2.00% | 6.00% |
No emergency visit | 80.00% | 86.00% | 74.00% |
Length of stay in hospital emergency room (hours) | |||
Mild | 4.0 | 3.0 | 6.0 |
Moderate | 7.0 | 5.0 | 9.0 |
Severe | 16.0 | 12.0 | 20.0 |
Length of stay in primary care emergency room (hours) | |||
Mild | 2.0 | 1.0 | 3.0 |
Moderate | 4.0 | 3.0 | 5.0 |
Severe | 6.0 | 4.0 | 8.0 |
Length of stay at the HAE specialist (hours) | |||
Mild | 1.5 | 1.0 | 2.0 |
Moderate | 2.0 | 1.0 | 3.0 |
Severe | 5.0 | 4.0 | 6.0 |
Round trip distance to healthcare facility (Km) | |||
To hospital | 30.00 | 20.00 | 40.00 |
To primary care centre | 4.00 | 2.00 | 6.00 |
Round trip travel time (minutes) | |||
To hospital | 45.00 | 30.00 | 60.00 |
To primary care centre | 15.00 | 10.00 | 20.00 |
Timing of episodes among gainfully employed (%) | |||
Work hours | 21.92% | ||
Non work hours | 78.08% | ||
Timing of episodes among unpaid homemakers (%) | |||
Work hours | 30.59% | ||
Non work hours | 69.41% | ||
% episode duration during which unable to work | |||
Mild | 0.00% | 0.0% | 0.0% |
Moderate | 40.00% | 30.0% | 50.0% |
Severe | 80.00% | 70.0% | 90.0% |
Probability (%) patient comes with a caretaker (by age group and episode severity) | |||
18-64 years/mild | 50.0% | 40.0% | 60.0% |
18-64 years/moderate | 60.0% | 50.0% | 70.0% |
18-64 years/severe | 95.0% | 90.0% | 100.0% |
≥ 65 years/mild | 70.0% | 60.0% | 80.0% |
≥ 65 years/moderate | 80.0% | 70.0% | 95.0% |
≥ 65 years/severe | 95.0% | 90.0% | 100.0% |
% of episode duration patient requires caretaker (by age group and episode severity) | |||
18-64 years/mild | 0.0% | 0.0% | 0.0% |
18-64 years/moderate | 20.0% | 15.0% | 30.0% |
18-64 years/severe | 70.0% | 60.0% | 80.0% |
≥ 65 years/mild | 0.0% | 0.0% | 0.0% |
≥ 65 years/moderate | 40.0% | 30.0% | 50.0% |
≥ 65 years/severe | 80.0% | 70.0% | 90.0% |
Icatibant syringes per episode | |||
Mild | 1.00 | 0.90 | 1.10 |
Moderate | 1.10 | 1.00 | 1.20 |
Severe | 1.10 | 1.00 | 1.30 |
With strategy 1, during a severe episode the probability (%) of: | |||
Death | 0.01% | 0.005% | 0.015% |
Tracheotomy | 0.20% | 0.10% | 0.30% |
Hospital admission | 0.40% | 0.30% | 0.50% |
Length of admission for severe episode (days): | |||
General ward | 2.00 | 1.00 | 3.00 |
ICU | 2.00 | 1.00 | 3.00 |
With strategy 2, during a severe episode the probability (%) of: | |||
Death | 0.0010% | 0.0005% | 0.0015% |
Tracheotomy | 0.0200% | 0.0100% | 0.0300% |
Hospital admission | 0.1000% | 0.0500% | 0.1500% |