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Table 3 Variables and their distribution values used in PSA testing

From: Will vaccination against rotavirus infection with RIX4414 be cost-saving in Germany?

Variable

Distribution type

Mean

Source

Average number of days staying at home after consultation visit

General (2,3,4,5,6,7; 0.05,0.05,0.15,0.2,0.3,0.25)

5.2

[11]

Average number of days staying at home due to hospitalisation

General (2,3,4,5,6,7; 0.05,0.02,0.02,0.25,0.25,0.05)

4.6

[56]

Average number of days staying at home due to nosocomial rotavirus infection

Gamma (2,1)

2

[26]

Proportion of families with both parents working

Normal (0.31, 0.031; truncated 0.1,0.55)

31%

[47]

Proportion seeking medical advice

Beta general (6.5,7; 0.65,0.9)

77%

[1]

Probability of hospitalisation

Beta general (10,5; 0.17,0.26)

23%

[9]

Probability of nosocomial infection in the first year

Beta general (6,4; 0.01,0.048)

3.28%

[3133]

Vaccine efficacy for mild RVGE, 1 year, 1 dose

Normal (0.784; 0.03)

0.784

[36, 38]

Vaccine efficacy for moderate RVGE, 1 year, 1 dose

Normal (0.808; 0.03)

0.808

[36, 38]

Vaccine efficacy for severe RVGE, 1 year, 1 dose

Normal (0.900; 0.03)

0.900

[36, 38]

Vaccine efficacy for mild RVGE, 1 year, 2 doses

Normal (0.871; 0.03)

0.871

[36, 38]

Vaccine efficacy for moderate RVGE, 1 year, 2 doses

Normal (0.898; 0.03)

0.898

[36, 38]

Vaccine efficacy for severe RVGE, 1 year, 2 doses

Normal (1.000; 0.1; truncated (0.871; 1)

0.94

[36, 38]

Age-specific incidence rate of diarrhoea

Normal (0.023; 0.0023)

0.023

 

Vaccine coverage rate

Uniform (0.75;1)

87.5%

 

Discount rate on cost

Discrete (0,0.75,1,1.5)

3%

 
  1. PSA probabilistic sensitivity analysis, RVGE rotavirus gastroenteritis.