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Table 1 SIFRA indicators

From: Severity index for rheumatoid arthritis and its association with health care costs and biologic therapy use in Turkey

 

Rating 1

Radiology and Laboratory Findings

Mean (Range)

Presence of RF Ever

2.7 (2–4)

 Presence of HLA Subtype

3.0 (1–4)

C1-2 Subluxation

5.2 (5–6)

Presence of CCP Ever

3.0 (2–4)

Clinical and Functional Status Measures

 

Number of Rheumatologist Visits

3.2 (2–4)

Extra-articular Manifestations

 

Pulmonary Nodules

3.5 (3–5)

Subcutaneous Nodules

2.8 (2–4)

Vasculitis Ever

5.0 (4–6)

Felty's Syndrome Ever

5.0 (4–6)

Surgical History

 

Cervical Spine Fusion

5.5 (5–6)

Foot Joint Replacement

4.2 (2–6)

Total Hip Replacement

5.2 (4–6)

Total Knee Replacement

5.2 (4–6)

Elbow Replacement

5.3 (4–6)

Shoulder Replacement

5.5 (5–6)

Medications

 

Any Oral Glucocorticoid Use

2.8 (2–4)

Intra-articular Glucocorticoids

2.7 (2–4)

Disease-modifying Anti-rheumatic Drugs

 

Azathioprine

4.2 (3–5)

Cyclosporin

4.5 (4–5)

Hydroxychloroquine

2.0 (2)

Leflunomide

3.8 (3–4)

Methotrexate

3.8 (3–4)

Sulfasalazine

2.3 (2–3)

Biologic Therapies

 

Adalimumab

4.2 (4–5)

Infliximab

4.0 (3–5)

Etanercept

4.2 (4–5)

TNF (ADA, ETN, IFX)

4.1

Non-TNF (ABA, RTX)

4.8

  1. RF=rheumatoid factor; HLA=human leukocyte antigen; C1-2=cervical spine 1-2; CCP=anti-cyclic citrullinated peptide; TNF=tumor necrosis factor; ADA=adalimumab; ETN=etanercept; IFX=infliximab; ABA=abatacept; RTX = rituximab.
  2. Note: For new biologic therapies approved since the “Delphi panel”, average scores were applied depending on class. For adalimumab, infliximab, etanercept, average of TNF blockers, a rating of 4.1 was applied; for abatacept and rituximab, average of non-TNF (4.8) was applied. Also medium and small joint fusion (4.825) and large joint fusion (5.3) was applied.