Table 1 Summary of study characteristics
Publication | Model type | Perspective | Cycle length | Time horizon | DAS | PSA | Efficacy measure | Clinical measure |
|---|---|---|---|---|---|---|---|---|
Beresniak 2011[26] Spain | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
Beresniak 2013[30] Germany | Decision Tree | TTP | 6 months | 2 years | No | No | Effect on DAS28-Score | DAS28-Score |
Chiou 2004[31] USA | Decision Tree | TTP | 6 months | 1 year | Yes | No | ACR | ACR/VAS-Score |
Choi 2000[24] USA | Decision Tree | Societal | Not applicable | 6 months | Yes | No | ACR | - |
Choi 2002[16] USA | Decision Tree | Societal | Not applicable | 6 months | Yes | No | ACR | ACR Response/ No Response |
Cimmino 2011[27] Italy | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
Kavanaugh 1996[23] USA | Decision Tree | Not stated (Societal) | Not applicable | 6 months | Yes | No | - | Response, Partial Response, No Response |
Moore 2004[20] UK | Decision Tree | TTP | Not applicable | life-time | Yes | Yes | Reduction in Complications | Complications |
Puolakka 2012[28] Finnland | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
Russell 2009[25] Canada | Decision Tree | TTP | ?6 months | 2 years | No | Yes | Effect on DAS-Score | DAS-Score |
Saraux 2010[29] France | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
Spiegel 2003[21] USA | Decision Tree | TTP | Not applicable | life-time | Yes | Yes | Reduction in Complications | Complications |
Zabinski 2001[22] Canada | Decision Tree | TTP | Not applicable | life-time | Yes | No | Reduction in Complications | Complications |
Bae 2003[47] Korea | Markov Model | Not stated | 12 months | life-time | Yes | No | Reduction in Complications | Complications |
Barbieri 2005[45] UK | Markov Model | TTP | 6 months | life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
Bessette 2009[55] Canada | Markov Model | TTP | 1 month | 5 years | Yes | No | Reduction in Complications | Complications |
Kobelt 1999[33] Sweden | Markov Model | Not stated (Societal) | 12 months | 5 years | No | No | Effect on HAQ-Score | HAQ-Score |
Kobelt 2002[34] Sweden & UK | Markov Model | Societal | 12 months | 10 years | No | No | Effect on HAQ-Score | HAQ-Score |
Kobelt 2003[32] Sweden & UK | Markov Model | Not stated (Societal) | 12 months | 10 years | Yes | No | Effect on HAQ-Score | HAQ-Score |
Kobelt 2005[35] Sweden | Markov Model | not stated | not stated | 10 years | No | Yes | not stated | HAQ Score & VAS Score |
Kobelt 2005a[36] Sweden | Markov Model | Societal | 12 months | 10 years | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Kobelt 2011[37] Sweden | Markov Model | Societal | 6 months | 10 years | No | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
Lekander 2010[39] Sweden | Markov Model | Societal | ?12 months | 20 years | Yes | No | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
Lekander 2012[38] Sweden | Markov Model | Societal | 12 months | 20 years | Yes | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
Lekander 2013[40] Sweden | Markov Model | Not stated | 12 months | 10 years | No | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
Maetzel 2002[49] Canada | Markov Model | TTP | 6 months | 5 years | No | Yes | - | ACR20 Response |
Maetzel 2003[48] Canada | Markov Model | TTP | 3 months | 5 years | Yes | No | Reduction in Complications | Complications |
Marra 2007[52] Canada | Markov Model | Societal | 1 week | 10 years | No | Yes | Effect on HAQ-Score | HAQ-Score |
Nguyen 2012[53] USA | Markov Model | TTP | 3 months | 5 years | Yes | Yes | - | ACR50 Response |
SchÓ“dlich 2004[55] Germany | Markov Model | TTP | 6 months | 3 years | Yes | No | - | ACR20 Response |
Schipper 2011[42] The Netherlands | Markov Model | Societal | 3 months | 5 years | Yes | Yes | Effect on DAS28-Score | DAS28-Score |
Spalding 2006[50] USA | Markov Model | Societal | 12 months | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
Tanno 2006[51] Japan | Markov Model | Not stated (Societal) | 6 months | Life-time | Yes | No | ACR | HAQ-Score |
Welsing 2004[41] The Netherlands | Markov Model | not stated | 3 months | 5 years | Yes | Yes | EULAR &ACR | DAS-Score |
Wong 2002[43] USA | Markov Model | Societal | 6 months | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
Wu 2012[56] China | Markov Model | TTP | 6 months | Life-time | Yes | Yes | - | ACR20/50/70 Response |
Yun 2005[47] Korea | Markov Model | Societal | 12 months | Life-time | Yes | No | Reduction in Complications | Complications |
Bansback 2005[57] Sweden | ISM | Not stated (TTP) | 6 months | Life-time | Yes | Yes | ACR | HAQ-Score |
Brennan 2004[15] UK | ISM | Societal | 6 months | Life-time | Yes | No | ACR | HAQ-Score |
Brennan 2007[58] UK | ISM | TTP | 6 months | Life-time | Yes | Yes | EULAR | HAQ Score |
Diamantpoulus 2012[68] Italy | ISM | TTP | 6 months | Life-time | Yes | Yes | - | ACR20/50/70 Response |
Finckh 2009[60] USA | ISM | Societal | 6 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Hallinen 2010[63] Finnland | ISM | Societal | 6 months | 100 years | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Kielhorn 2008[61] UK | ISM | TTP | 6 months | Life-time | Yes | Yes | ACR | HAQ Score |
Merkesdahl 2010[62] Germany | ISM | TTP | 6 months | 100 years | Yes | Yes | ACR | HAQ-Score |
Soini 2012[64] Finnland | ISM | Societal | 6 months | Life-time | Yes | Yes | ACR | HAQ Score |
Vera-Llonch 2008[65] USA | ISM | TTP | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Vera-Llonch 2008a[66] USA | ISM | Not stated | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Wailoo 2008[59] USA | ISM | TTP | 6 months | Life-time | Yes | Yes | ACR | HAQ-Score |
Yuan 2010[67] USA | ISM | TTP | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
Barton 2004[70] UK | DES | Not stated | Not applicable | Life-time | No | No | Effect on HAQ-Score | HAQ-Score |
Chen 2006[71] UK | DES | TTP | Not applicable | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
Clark 2004[17] UK | DES | TTP | Not applicable | Not stated | Yes | No | Effect on HAQ-Score | HAQ-Score |
Jobanputra 2002[69] UK | DES | Not stated | Not applicable | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
Kobelt 2009[74] Sweden | DES | Societal | Not applicable | 10 years | Yes | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
Lindgren 2009[73] Sweden | DES | Societal | Not applicable | Life-time | Yes | Yes | ACR | HAQ-Score & DAS28-Score |
Malottki 2011[72] UK | DES | Not stated (TTP) | Not applicable | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |