Table 1 Overview of cost and effect input data applied in the model
Parameter | Mean input value | Standard deviation | Distribution |
|---|---|---|---|
Age at Therapy Start | 51.1 | 5.3 | Normal |
Health State Costs ‘Visual Impaired’ | €3,680 | €368 | Normal |
Health State Costs ‘Blind’ | €4,091 | €409 | Normal |
Health State Costs ‘Death’ | €0 | €0 | None |
AVD Costs, first year (Base Case) | €85,000 | €8,500 | Normal |
AVD Costs, first year (Scenario 1) | €55,000 | €5,500 | Normal |
AVD Costs, first year (Scenario 2) | €70,000 | €7,000 | Normal |
AVD Costs, first year (Scenario 3) | €100,000 | €10,000 | Normal |
AVD Costs, first year (Scenario 4) | €115,000 | €11,500 | Normal |
AVD Costs, annual follow-up | €1,500 | €150 | Normal |
Health State Utility ‘Visual Impaired’ | 0.77 | 0,077 | Normal |
Health State Utility ‘Blind’ | 0.61 | 0.061 | Normal |
Health State Utility ‘Death’ | 0 | 0 | None |
Responder Rate AVD (Base Case) | 62.5% | None | None |
Responder Rate AVD (Scenario 1) | 25% | None | None |
Responder Rate AVD (Scenario 2) | 50% | None | None |
Responder Rate AVD (Scenario 3) | 75% | None | None |
Responder Rate AVD (Scenario 4) | 100% | None | None |
Discounting of Costs | 3% | None | None |
Discounting of Effects | 3% | None | None |