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Table 1 Model inputs

From: Cost effectiveness of lanthanum carbonate in chronic kidney disease patients in Spain before and during dialysis

  Predialysis value (95% CI) Dialysis value (95% CI)
Average patient age 60 years
Gender 60% male
Renal disease origin 20% diabetes, 17% hypertension/renal vascular disease, 15% glomerulonephritis, 48% other cause
Target SP levels <4.6 mg/dL [3]  
Initiation SP levels >4.6 mg/dL [19] >5.5 mg/dL [20]  
Drug efficacy    
Response rate to CB 44.5% (32.1-57.1) [21] 34.1%(31.0-37.4) [22]  
Response rate to LC 38.3% (32.7-44.0) [19] 16.6% (13.5-19.9) [22]  
Drug dosage    
CC 3,000 mg/day 1,500 mg/day  
CA 5,000 mg/day 3,000 mg/day  
LC 1,875 mg/day 2,250 mg/day  
Baseline yearly mortality 12.3% [16]   
CKD baseline yearly progression 14.3% (13.6-15.0) [19]  
RR of mortality by SP level   For SA only
<2.5 mg/dL 0.95 (0.69-1.32) [17] 1.00 (0.96-1.24) [18] 1.00 (0.87-1.15)
2.5 mg/dL-3.0 mg/dL 1.00 (1.00-1.00) [17] 1.00 (0.96-1.24) [18] 1.00 (0.87-1.15)
3.0 mg/dL-3.5 mg/dL 1.15 (0.95-1.39) [17] 1.00 (0.93-1.07) [18] 1.00 (0.87-1.15)
3.5 mg/dL-4.0 mg/dL 1.32 (1.09-1.61) [17] 1.00 (0.93-1.07) [18] 1.00 (0.87-1.15)
4.0 mg/dL-4.5 mg/dL 1.34 (1.05-1.71) [17] 1.00 (1.00-1.00) [18] 1.00 (0.87-1.15)
4.5 mg/dL-5.0 mg/dL 1.83 (1.33-2.51) [17] 1.00 (1.00-1.00) [18] 1.00 (1.00-1.00)
5.0 mg/dL-5.5 mg/dL 1.90 (1.30-2.79) [17] 1.07 (1.01-1.14) [18] 1.00 (1.00-1.00)
5.5 mg/dL-6.0 mg/dL 1.90 (1.10-1.29) [17] 1.07 (1.01-1.14) [18] 1.02 (0.89-1.17)
6.0 mg/dL-7.0 mg/dL 1.90 (1.10-1.29) [17] 1.25 (1.17-1.34) [18]  
7.0 mg/dL-8.0 mg/dL 1.90 (1.10-1.29) [17] 1.43 (1.31-1.54) [18] 1.18 (1.02-1.36)¥
8.0 mg/dL-9.0 mg/dL 1.90 (1.10-1.29) [17] 1.67 (1.51-1.86) [18] 1.39 (1.21-1.60)
>9.0 mg/dL 1.90 (1.10-1.29) [17] 2.02 (1.76-2.27) [18] 1.39 (1.21-1.60)
Utilities    
Disease stage utility 0.71 [24] 0.61 [24]  
  1. CA: calcium acetate; CC: calcium carbonate; CKD: Chronic Kidney Disease; CI: confidence interval; LC: lanthanum carbonate; RR: relative risk; SA: Sensitivity analysis; SP: Serum phosphorus.
  2. from 5.5 mg/dL – 6.5 mg/dL.
  3. ¥from 6.6 mg/dL – 7.8 mg/dL.