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Table 4 Drug and Event costs (in 2012 US Dollars)

From: Estimation of the cost-effectiveness of apixaban versus vitamin K antagonists in the management of atrial fibrillation in Argentina

Item Cost (USD) [min-max] Unit Duration of the event Source
Drugs     
Apixaban 5 mg (BID) 1.49 Per day -- [30]
Warfarin (5 mg/day average dose) 0.15 Per day   
Monitoring Visit (applicable to warfarin only) 11.85 [9.24-14.45] Per visit -- *
Routine Care 1.11 [0.86-1.35] Per visit -- *
Stroke (excluding hemorrhagic stroke)     
Mild     [31, 32]
Acute Care 1450.33 [1131.25-1769.4] Per episode 2 weeks
Long-term Maintenance 1110.20 [865.95-1354.44] Per month Lifetime
Moderate     
Acute Care 2813.25 [2194.33-3432.16] Per episode 2 weeks [31, 32]
Per month Lifetime
Long-term Maintenance 1110.20 [865.95-1354.44]
Severe     
Acute Care 4084.26 [3185.72-4982.79] Per episode 2 weeks [31, 32]
Per month Lifetime
Long-term Maintenance 1110.20 [865.95-1354.44]
Fatal Ischemic Stroke 2813.25 [2194.33-3432.16] Per episode   
Heamorrhagic Stroke     
Mild     
Acute Care 3740.68 [2917.73-4563.62] Per episode 2 weeks [31, 32]
Long-term Maintenance 1110.20 [865.95-1354.44] Per month Lifetime
Moderate     [31, 32]
Acute Care 6731.00 [5250.18 – 8211.82] Per episode 2 weeks
Long-term Maintenance 1110.20 [865.95-1354.44] Per month Lifetime
Severe     
Acute Care 13777.79 [10746.67-16808.9] Per episode 2 weeks [31]
Long-term Maintenance 1110.20 [865.95-1354.44] Per month Lifetime
Fatal Heamorrhagic Stroke 6731.00 [5250.18-8211.82] Per episode   **
Systemic Embolism     
Acute Care 2900.04 [2262.03-3538.04] Per episode 2 weeks [33]
Long-term Maintenance 229.11 [178.70-279.52] Per month Lifetime  
Other ICH (excluding heamorrhagic stroke) 6622.09 [5165.23-8078.94] Per episode -- [31, 33] *
Other Major Bleeds    --  
(excluding ICH)     
GI Bleeds 3829.17 [2986.75-4671.58] Per episode   
Non ICH and Non GI Related Major Bleeds 3829.17 [2986.75-4671.58] Per episode
    -- [33]
-- [33]
CRNM Bleeds 2055.04 [750.7-1284.28] Per episode -- [33]
Myocardial Infarction     
Acute Care 2211.52 [1748.00-2797.90] Per episode -- [32]
Long-term Maintenance 1110.20 [865.95-1354.44] Per month Lifetime [32] *
Other CV Hospitalization 2211.52 [1139.70-1797.70] Per episode -- [32]
  1. GI bleeds gastrointestinal bleeds; ICH intracranial hemorrhage; CRNM bleed clinically relevant non-major bleeds
  2. *Based on a local Health Resource Cost Data Base
  3. **we assumed that fatal stroke (both ischemic or haemorrhagic) has a cost equivalent to a moderate stroke(both ischemic or haemorrhagic) reported by Christensen et al. [31]