Estimation of the cost-effectiveness of apixaban versus vitamin K antagonists in the management of atrial fibrillation in Argentina

Giorgi, Mariano Anibal; Caroli, Christian; Giglio, Norberto Damian; Micone, Paula; Aiello, Eleonora; Vulcano, Cristina; Blanco, Julia; Donato, Bonnie; Quevedo, Joaquin Mould

doi:10.1186/s13561-015-0052-8

Table 4 Drug and Event costs (in 2012 US Dollars)

From: Estimation of the cost-effectiveness of apixaban versus vitamin K antagonists in the management of atrial fibrillation in Argentina

Item	Cost (USD) [min-max]	Unit	Duration of the event	Source
Drugs
Apixaban 5 mg (BID)	1.49	Per day	--	[30]
Warfarin (5 mg/day average dose)	0.15	Per day
Monitoring Visit (applicable to warfarin only)	11.85 [9.24-14.45]	Per visit	--	*
Routine Care	1.11 [0.86-1.35]	Per visit	--	*
Stroke (excluding hemorrhagic stroke)
Mild				[31, 32]
Acute Care	1450.33 [1131.25-1769.4]	Per episode	2 weeks
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime
Moderate
Acute Care	2813.25 [2194.33-3432.16]	Per episode	2 weeks	[31, 32]
Acute Care	2813.25 [2194.33-3432.16]	Per month	Lifetime
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime
Severe
Acute Care	4084.26 [3185.72-4982.79]	Per episode	2 weeks	[31, 32]
Acute Care	4084.26 [3185.72-4982.79]	Per month	Lifetime
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime
Fatal Ischemic Stroke	2813.25 [2194.33-3432.16]	Per episode
Heamorrhagic Stroke
Mild
Acute Care	3740.68 [2917.73-4563.62]	Per episode	2 weeks	[31, 32]
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime	[31, 32]
Moderate				[31, 32]
Acute Care	6731.00 [5250.18 – 8211.82]	Per episode	2 weeks
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime
Severe
Acute Care	13777.79 [10746.67-16808.9]	Per episode	2 weeks	[31]
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime	[31]
Fatal Heamorrhagic Stroke	6731.00 [5250.18-8211.82]	Per episode		**
Systemic Embolism
Acute Care	2900.04 [2262.03-3538.04]	Per episode	2 weeks	[33]
Long-term Maintenance	229.11 [178.70-279.52]	Per month	Lifetime
Other ICH (excluding heamorrhagic stroke)	6622.09 [5165.23-8078.94]	Per episode	--	[31, 33] *
Other Major Bleeds			--
(excluding ICH)
GI Bleeds	3829.17 [2986.75-4671.58]	Per episode
Non ICH and Non GI Related Major Bleeds	3829.17 [2986.75-4671.58]	Per episode
			--	[33]
			--	[33]
CRNM Bleeds	2055.04 [750.7-1284.28]	Per episode	--	[33]
Myocardial Infarction
Acute Care	2211.52 [1748.00-2797.90]	Per episode	--	[32]
Long-term Maintenance	1110.20 [865.95-1354.44]	Per month	Lifetime	[32] *
Other CV Hospitalization	2211.52 [1139.70-1797.70]	Per episode	--	[32]

GI bleeds gastrointestinal bleeds; ICH intracranial hemorrhage; CRNM bleed clinically relevant non-major bleeds
*Based on a local Health Resource Cost Data Base
**we assumed that fatal stroke (both ischemic or haemorrhagic) has a cost equivalent to a moderate stroke(both ischemic or haemorrhagic) reported by Christensen et al. [31]

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ISSN: 2191-1991

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