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Table 1 Overall rates of adverse events observed in CONDOR, MEDAL, CLASS, EDGE and TARGET [6, 1115]

From: The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia

Treatment options Overall rates of adverse events/patient (% ± SD)
GI symptoms Symptomatic ulcer Complicated GI event Myocardial infarction Stroke Heart failure
Diclofenac 21.30 (±0.9) 0.14 (±0.02) 0.07 (±0.01) 0.09 (±0.01) 0.06 (±0.01) 0.02 (±0.01)
Ibuprofen 12.72 (±0.54) 0.20 (±0.09) 0.08 ((±0.04) 0.15 (±0.11) 0.06 (±0.04) 0.09 (±0.12)
Celecoxib 12.45 (±0.46) 0.09 (±0.04) 0.05 (±0.03) 0.15 (±0.10) 0.02 (±0.02) 0.04 (±0.06)
Etoricoxib 10.40 (±0.43) 0.14 (±0.02) 0.05 (±0.03) 0.10 (±0.01) 0.06 (±0.01) 0.02 (±0.01)
  1. GI, gastrointestinal; SD, standard deviation