Table 1 Overall rates of adverse events observed in CONDOR, MEDAL, CLASS, EDGE and TARGET [6, 11–15]
Treatment options | Overall rates of adverse events/patient (% ± SD) | |||||
|---|---|---|---|---|---|---|
GI symptoms | Symptomatic ulcer | Complicated GI event | Myocardial infarction | Stroke | Heart failure | |
Diclofenac | 21.30 (±0.9) | 0.14 (±0.02) | 0.07 (±0.01) | 0.09 (±0.01) | 0.06 (±0.01) | 0.02 (±0.01) |
Ibuprofen | 12.72 (±0.54) | 0.20 (±0.09) | 0.08 ((±0.04) | 0.15 (±0.11) | 0.06 (±0.04) | 0.09 (±0.12) |
Celecoxib | 12.45 (±0.46) | 0.09 (±0.04) | 0.05 (±0.03) | 0.15 (±0.10) | 0.02 (±0.02) | 0.04 (±0.06) |
Etoricoxib | 10.40 (±0.43) | 0.14 (±0.02) | 0.05 (±0.03) | 0.10 (±0.01) | 0.06 (±0.01) | 0.02 (±0.01) |