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Table 4 Discounts by benefit categories and indication class (Orphan drugs)

From: Benefit assessment in Germany: implications for price discounts

Additional benefit: overall      
Indication class by ICD-10 n Mean Min Max SD
Diseases of the respiratory system 1 10.96 10.96 10.96
Diseases of the circulatory system 3 22.31 20.72 25.49 2.75
Neoplasms 16 19.59 9.00 29.78 5.82
Other 1 24.50 24.50 24.50
Endocrine, nutritional and metabolic diseases 6 12.43 1.00 25.31 10.17
Diseases of the digestive system 2 20.21 14.87 25.54 7.54
Overall 29 18.31 1.00 29.78 7.27
Size of target population (upper level) 29 1896 11 7850 2583
Additional benefit: considerable
Indication class by ICD-10 n Mean Min Max SD
Neoplasms 2 20.80 19.78 21.81 1.44
Endocrine, nutritional and metabolic diseases 1 5.05 5.05 5.05
Overall 3 15.55 5.05 21.81 9.15
Size of target population (upper level) 3 2348 143 5000 2459
Additional benefit: minor
Indication class by ICD-10 n Mean Min Max SD
Diseases of the circulatory system 3 22.31 20.72 25.49 2.75
Neoplasms 3 21.55 13.85 25.81 6.68
Other 1 24.50 24.50 24.50
Endocrine, nutritional and metabolic diseases 5 13.91 1.00 25.31 10.62
Diseases of the digestive system 1 25.54 25.54 25.54
Overall 13 19.32 1.00 25.54 8.21
Size of target population (upper level) 13 2167 11 7850 2924
Additional benefit: non-quantifiable
Indication class by ICD-10 n Mean Min Max SD
Diseases of the respiratory system 1 10.96 10.96 10.96
Neoplasms 11 18.84 9.00 29.78 6.29
Diseases of the digestive system 1 14.87 14.87 14.87
Overall 13 17.93 9.00 29.78 6.21
Size of target population (upper level) 13 1521 25 7500 2393
  1. All discounts presented in %
  2. Abbreviations: Min minimum, Max maximum, SD standard deviation