Conditional appraisals (N = 12) | Unconditional appraisals (N = 9) | Total (N = 21) | |
---|---|---|---|
Number of RCTs presented in manufacturer’s dossier (mean ± SD) | 1.3 ± 1.2 | 1.0 ± 0.5 | 1.2 ± 1.0 |
Number of patients in largest RCT (mean ± SD) | 577 ± 207 | 939 ± 361 | 729 ± 329 |
Number of control arms (mean ± SD) | 1.1 ± 0.3 | 1.0 ± 0 | 1.1 ± 0.2 |
Use of an active control (n, %) | 8 (67 %) | 3 (33 %) | 11 (52 %) |
Benefit outcome influenced by potential for bias | 8 (67 %) | 1 (11 %) | 9 (43 %) |
Direct comparison to appropriate comparator available | 9 (75 %) | 7 (78 %) | 16 (76 %) |