Parametersa | Base case | Deterministic | Probabilistic | Reference/ Sources | |
---|---|---|---|---|---|
Low value | High value | Distribution | |||
Transition probabilitiesb | |||||
pSevere | 0.271 | 0.187 | 0.355 | Dirichlet (α1 = 29, α2 = 78) | 12 |
pModerate | 0.355 | 0.264 | 0.446 | Dirichlet (α1 = 38, α2 = 69) | 12 |
pMild | 0.374 | 0.282 | 0.466 | Dirichlet (α1 = 40, α2 = 67) | 12 |
pSevere_C | 0.759 | 0.603 | 0.914 | Beta (α = 22, β = 7) | 12 |
pModerate_C | 0.632 | 0.478 | 0.785 | Beta (α = 24, β = 14) | 12 |
pMild_C | 0.375 | 0.225 | 0.525 | Beta (α = 15, β = 25) | 12 |
pSevere_HighR | 0.931 | 0.839 | 1.023 | Dirichlet (α1 = 27, α2 = 2) | 12 |
pModerate_HighR | 0.158 | 0.042 | 0.274 | Dirichlet (α1 = 6, α2 = 32) | 12 |
pMild_HighR | N/A | N/A | N/A | Dirichlet (α1 = 0, α2 = 40) | 12 |
pSevere_MediumR | 0.069 | 0.000 | 0.161 | Dirichlet (α1 = 2, α2 = 27) | 12 |
pModerate_MediumR | 0.842 | 0.726 | 0.958 | Dirichlet (α1 = 32, α2 = 6) | 12 |
pMild_MediumR | 0.500 | 0.345 | 0.655 | Dirichlet (α1 = 20, α2 = 20) | 12 |
pSevere_LowR | N/A | N/A | N/A | Dirichlet (α1 = 0, α2 = 29) | 12 |
pModerate_LowR | N/A | N/A | N/A | Dirichlet (α1 = 0, α2 = 38) | 12 |
pMild_LowR | 0.500 | 0.345 | 0.655 | Dirichlet (α1 = 20, α2 = 20) | 12 |
pSevere_HighR_C | 0.815 | 0.668 | 0.961 | Beta (α = 22, β = 5) | 12 |
pModerate_HighR_C | 0.833 | 0.535 | 1.132 | Beta (α = 5, β = 1) | 12 |
pMild_HighR_C | N/A | N/A | N/A | Beta (α = 0, β = 0) | 12 |
pSevere_MediumR_C | N/A | N/A | N/A | Beta (α = 0, β = 2) | 12 |
pModerate_MediumR_C | 0.594 | 0.424 | 0.764 | Beta (α = 19, β = 13) | 12 |
pMild_MediumR_C | 0.550 | 0.332 | 0.768 | Beta (α = 11, β = 9) | 12 |
pSevere_LowR_C | N/A | N/A | N/A | Beta (α = 0, β = 0) | 12 |
pModerate_LowR_C | N/A | N/A | N/A | Beta (α = 0, β = 0) | 12 |
pMild_LowR_C | 0.200 | 0.025 | 0.375 | Beta (α = 4, β = 16) | 12 |
Relative risk of developing cancer with Excision (i.e. surgery) | |||||
rrMT | 0.51 | 0.230 | 1.140 | LogNormal (ln (mean = −0.673, SE = 0.408) | SR/MA |
Costs and Resources | |||||
cHistopathology | $ 88 | $ 70.4 | $ 105.6 | Gamma (α100=, β = 0.88) | 34 |
cBiomarker | $ 250 | $ 200 | $ 300 | Gamma (α = 100, β = 2.5) | Manufacturer |
cExcision | $ 384 | $ 307.2 | $ 460.8 | Gamma (α = 100, β = 3.84) | 34 |
cFollow-up | $ 129 | $ 103.2 | $ 154.8 | Gamma (α = 100, β = 1.29) | 34 |
cPathology | $ 95 | $ 76 | $ 114 | Gamma (α = 100, β = 0.95) | Experts Opinion |
cPainMed_T2 | $ 12.65 | $ 10.15 | $ 15.15 | Gamma (α = 100, β = 0.127) | Experts Opinion |
cPainMed_P | $ 25.17 | $ 22.67 | $ 27.67 | Gamma (α = 100, β = 0.252) | Experts Opinion |
cWork_Loss | 25.42 | 20.336 | 30.504 | Gamma (α = 100, β = 0.254) | 16 |
cTransportation | 0.575 | 0.46 | 0.69 | Gamma (α = 100, β = 0.00575) | 16 |
cParking | 20 times | 16 times | 24 times | Gamma (α = 100, β = 0.2) | Assumption |
HRSofWORK | 24 h | 0 h | 40 h | Gamma (α = 100, β = 0.240) | Experts Opinion |
avgDISTANCE | 60 Km | 48 Km | 72 Km | Gamma (α = 100, β = 0.600) | Assumption |
employed | 0.9271 | 0 | 0 | None | 16 |
V_E6M_year | 2 visits | 1 visits | 3 visits | None | Experts Opinion |
V_E3M_year | 4 visits | 3 visits | 5 visits | None | Experts Opinion |