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Table 3 Utility and cost parameters

From: Palivizumab in the prevention of severe respiratory syncytial virus infection in children with congenital heart disease; a novel cost-utility modeling study reflecting evidence-based clinical pathways in Spain

  Palivizumab/placebo (SE) Distribution in PSA Source
Utilities
 Baseline (age 0–17 years) 0.950 (0.162) Beta Greenough et al. (2004)
 Baseline (age 18–24 years) 0.982 (0.003) Beta Szende et al. (2014)
 Baseline (age 25–34 years) 0.975 (0.003) Beta Szende et al. (2014)
 Baseline (age 35–44 years) 0.949 (0.009) Beta Szende et al. (2014)
 Baseline (age 45–54 years) 0.923 (0.010) Beta Szende et al. (2014)
 Baseline (age 55–64 years) 0.901 (0.009) Beta Szende et al. (2014)
 Baseline (age 65–74 years) 0.891 (0.007) Beta Szende et al. (2014)
 Baseline (age 75 years onwards) 0.781 (0.014) Beta Szende et al. (2014)
 Decrement: RSV-H 0.070 (0.014) Beta Greenough et al.(2004)
 Decrement: asthma 0.048 (0.010) Lognormal Briggs et al. (2006)
 Decrement: allergic sensitization 0.046 (0.009) Lognormal Brüggenjürgen et al. (2008)
Direct costs
 Prophylaxis cost € 2902 Fixed Synagis vial cost, Pedraz et al. (2003), Clinical expert input
 General ward hospital stay/day € 591 (€ 118) Gamma Lázaro y de Mercado et al. (2006)
 Intensive care support/day € 1041 (€ 208) Gamma Lázaro y de Mercado et al. (2006)
 Outpatient visit € 21 (€ 4) Gamma Dal Negro et al. (2007)
 Asthma/year € 744 (€ 149) Gamma Blasco Bravo et al. (2011)
 Allergy/year € 198 (€ 40) Gamma Smith et al. (2005)
 RSV-H (pediatric ward), days 7 (1.4) Gamma Medrano et al. (2010)
 RSV-H – ICU, days 10 (2.0) Gamma Medrano et al. (2010)
 Risk of ICU admission, % 30.4 (6.1) Beta Medrano et al. (2010)
 Delayed surgery (outpatient), GP visits 4 (0.8) Gamma Expert opinion
 Delayed surgery (inpatient), days 28 (5.6) Gamma Expert opinion
 Immediate surgery, days 2.1 (0.42) length of stay in pediatric ward Gamma Altman et al. (2000)
Indirect costs
 Missed work: Palivizumab administration, hours 2 (0.4) Gamma Assumption
 Missed work: MA-RSV, hours 2 (0.4) Gamma Assumption
 Missed work: RSV-H, hours 57 (11.5) Gamma Medrano et al. (2010), Assumption
 Asthma/year € 495 (€ 99) Gamma Blasco Bravo et al. (2011)
 Allergy/year € 259 (€ 52) Gamma Smith et al. (2005)
 Nosocomial infection: risk, % 6.1 (0.6) Beta Ehlken et al. (2005)
 Nosocomial infection (pediatric ward), days 14 (2.8) Gamma Assumption, Expert opinion
 Absence from work/hour € 20 (€ 4) Gamma Anuario Estadístico de Espana (2017; Spanish statistical yearbook)
  1. Notes: Presented costs were either 2016 costs or were inflated to 2016 costs
  2. Abbreviations: GP, general practitioner, SE, standard error; PSA, probabilistic sensitivity analysis; RSV, respiratory syncytial virus; RSV-H, RSV infection resulting in hospitalization; ICU, intensive care unit; MA-RSV, medically attended RSV infection