Understanding the adoption of new drugs decided by several stakeholders in the South Korean market: a nonparametric event history analysis

Table 1 Results for the discrete factor effects and the linear effects from the Cox model with the duration as outcome

Variable	Model 1 (approval_decision)			Model 2 (approval_trial)			Model 3 (trial_decision)			Model 3_1 (trial_decision)
Variable	Coefficient	Standard Error	p-value	Coefficient	Standard Error	p-value	Coefficient	Standard Error	p-value	Coefficient	Standard Error	p-value
Manufacturing types
locally manufactured (Ref. import)	−0.097	0.317	0.760	0.208	0.326	0.523	−0.276	0.320	0.388	−0.305	0.320	0.340
locally developed and manufactured	1.064	0.349	0.002	0.784	0.338	0.020	0.349	0.355	0.325	0.287	0.356	0.420
Product types
biologics (Ref. chemicals)	−0.650	0.295	0.027	−0.787	0.310	0.011	−0.316	0.292	0.279	−0.194	0.299	0.515
Clinical effectiveness
improved (Ref. similar/non-inferior)	−0.597	0.253	0.018	−0.687	0.265	0.009	−0.443	0.259	0.087	−0.338	0.264	0.199
uncertain/others	−0.716	0.252	0.004	−0.320	0.240	0.183	−0.679	0.263	0.009	−0.609	0.265	0.021
ATC
ATC J or L (Ref. others)	−0.468	0.231	0.042	−0.010	0.242	0.968	−0.520	0.221	0.018	−0.481	0.217	0.026
Period
the second period (Ref. the first)	1.005	0.223	0.000	0.513	0.212	0.015	1.041	0.221	0.000	0.987	0.221	0.000
Duration
approval_trial										−0.024	0.015	0.099

ISSN: 2191-1991