Fig. 2

a Cost-effectiveness plane for the current therapy strategy versus the old therapy strategy. The results of 1000 simulations were plotted on the cost-effectiveness plane, with the majority of the simulations and probabilistic mean falling in the southeast quadrant. This indicated that the current therapy strategy was the dominant treatment strategy. Current therapy strategy: pegaspargase followed by Erwinia asparaginase. Old therapy strategy: native asparaginase followed by Erwinia asparaginase. QALY, quality-adjusted life years. b Tornado plot for incremental cost-effectiveness ratio of the current therapy strategy versus the old therapy strategy. Deterministic sensitivity analysis results indicated that ICER was stable for most parameters. The hypersensitivity rate for first-line treatment with native asparaginase for the paediatric population had the greatest impact on the ICER. Current therapy strategy: pegaspargase followed by Erwinia asparaginase. Old therapy strategy: native asparaginase followed by Erwinia asparaginase. EFS, event-free survival; HR, high risk; ICER, incremental cost-effectiveness ratio; IR, intermediate risk; OS, overall survival; QALY, quality adjusted life years; RR, relative risk; SR, standard risk