Intercept/Variable | Coefficient | Standard error | t-statistic | p-value |
---|---|---|---|---|
Additive premiums | ||||
EU prices (€) | ||||
  Intercept | 47,112.25243 | 5916.14299 | 7.96333904 | 0.00000682 |
  X Variable | 1.285149844 | 0.568349354 | 2.26119698 | 0.044997465* |
Comparable pharmaceuticals (€) | ||||
  Intercept | 48,424.19167 | 10,940.20482 | 4.426260061 | 0.001017904 |
  X Variable | 0.101908659 | 0.14325046 | 0.711401968 | 0.491646086 |
Extent of added benefit (minor, considerable) | ||||
  Intercept | 35,653.9575 | 18,946.75333 | 1.881797735 | 0.086573666 |
  X Variable | 12,040.5225 | 11,230.66868 | 1.072110917 | 0.306628308 |
AnTC of ACT (€) | ||||
  Intercept | 59,170.60488 | 7400.235335 | 7.995773405 | 0.00000657 |
  X Variable | −0.155870503 | 0.186811151 | −0.834374724 | 0.421820411 |
Target population size (N) | ||||
  Intercept | 70,019.62133 | 7424.38089 | 9.43103841 | 0.00000132 |
  X Variable | −2.195455811 | 0.862865137 | −2.5443789 | 0.02726661* |
Study design (substitutive, additive) | ||||
  Intercept | 52,933.98625 | 7243.390467 | 7.307901803 | 0.00001527 |
  X Variable | 5642.11975 | 11,679.61618 | 0.483074072 | 0.63851445 |
Study design (substitutive, additive curative ACT, additive BSC) | ||||
  Intercept | 36,397.2593 | 18,310.2111 | 1.98781211 | 0.07229695 |
  X Variable | 8106.2683 | 7572.83041 | 1.07044102 | 0.3073464 |
Multiplicative premiums | ||||
EU prices (€) | ||||
  Intercept | 314.560854 | 236.23716 | 1.33154688 | 0.20994402 |
  X Variable | 0.00380357 | 0.02269472 | 0.16759693 | 0.86994187 |
Comparable pharmaceuticals (€) | ||||
  Intercept | 987.783989 | 290.778295 | 3.39703481 | 0.00596027 |
  X Variable | −0.0099099 | 0.00380744 | −2.6027873 | 0.02457156* |
Extent of added benefit (minor, considerable) | ||||
  Intercept | 473.047535 | 656.418807 | 0.72064897 | 0.48615854 |
  X Variable | −83.468655 | 389.091577 | −0.2145219 | 0.83406515 |
AnTC of ACT (€) | ||||
  Intercept | 594.818068 | 223.036155 | 2.66691321 | 0.02191448 |
  X Variable | − 0.0098356 | 0.00563031 | −1.7468965 | 0.10847841 |
Target population size (N) | ||||
  Intercept | 380.835803 | 308.693069 | 1.23370377 | 0.243024 |
  X Variable | −0.0062737 | 0.03587646 | − 0.1748683 | 0.86436022 |
Study design (substitutive, additive) | ||||
  Intercept | 545.684925 | 219.766396 | 2.48302259 | 0.03041002 |
  X Variable | − 539.42557 | 354.362665 | −1.5222415 | 0.15616375 |
Study design (substitutive, additive curative ACT, additive BSC) | ||||
  Intercept | − 685.50644 | 547.170559 | −1.2528204 | 0.23624936 |
  X Variable | 443.611998 | 226.301588 | 1.96026904 | 0.07577965 |