Considering the societal perspective in economic evaluations: a systematic review in the case of depression

Duevel, Juliane Andrea; Hasemann, Lena; Peña-Longobardo, Luz María; Rodríguez-Sánchez, Beatriz; Aranda-Reneo, Isaac; Oliva-Moreno, Juan; López-Bastida, Julio; Greiner, Wolfgang

doi:10.1186/s13561-020-00288-7

Health Economics Review

Table 2 Summary of the economic results of the selected studies

From: Considering the societal perspective in economic evaluations: a systematic review in the case of depression

Author & publication year	N° of estimation	Healthcare perspective				Societal perspective				Change in		threshold value
Author & publication year	N° of estimation	∆Cost	∆QALY	ICUR (currency/QALY)	ICUR (2018€/QALY)	∆Cost	∆QALY	ICUR (currency/QALY)	ICUR (2018€/QALY)	results^a	conclusions^b	threshold value
Annemans et al. 2014 [26]	1	16	0.003	6352	6946	−258	0.003	−86,000	−94,049	YES	NO	30,000
	2	−5	0.004	− 1250	− 1367	− 387	0.004	−96,750	−105,805	NO	NO
	3	−37	0.008	− 4625	− 5058	− 829	0.008	−103,625	−113,323	NO	NO
	4	−50	0.009	− 5556	− 6076	− 902	0.009	−100,222	− 109,602	NO	NO
	5	−104	0.016	− 6500	− 7108	−1618	0.016	−101,125	− 110,589	NO	NO
	6	−128	0.015	− 8533	− 9332	− 1591	0.015	−106,067	− 115,994	NO	NO
	7	− 118	0.006	−19,667	−21,507	− 843	0.006	− 140,500	−153,650	NO	NO
Aragones et al. 2014 [27]	8	183	0.045	4056	4435	157	0.045	3499	3826	NO	NO	30,000
Banerjee et al. 2013 [28]	9	693	0.03	23,100	29,070	705	0.03	23,500	29,583	NO	NO	30,000
	10	404	0.05	8080	10,172	− 1106	0.05	−22,120	−27,962	YES	NO
	11	− 289	0.02	−14,450	−18,191	− 1811	0.02	−90,550	−113,990	NO	NO
Biesheuvel-Leliefeld et al. 2018 [29]	12	1107	0.03	33,025	35,216	2114	0.03	63,051	67,234	NO	NO	30,000
Bosmans et al. 2008 [30]	13	181	−0.00045	− 353,333	− 427,866	− 751	−0.00045	1,668,889	2,020,926	YES	NO	NA
Brettschneider et al. 2017 [31]	14	− 1031	0.0067	−153,881	−166,182	− 1309	0.0067	−195,373	− 210,991	NO	NO	50,000
Buntrock et al. 2017 [32]	15	135	0.01	13,500	14,396	134	0.01	13,400	14,289	NO	NO	20,000
Chalder et al. 2012 [33]	16	296	0.014	20,834	24,091	1813	0.014	129,500	149,744	NO	YES	30,000
Choi et al. 2016 [34]	17	−50,130	0.0131	− 3826,718	− 2765	−623,229	0.0131	−47,574,733	−34,379	NO	NO	NA
Dixon et al. 2016 [35]	18	177	0.031	5710	7463	324	0.031	10,452	13,662	NO	NO	30,000
Ekman et al. 2012 [36]	19	323	0.038	8591	11,076	485	0.043	11,173	14,405	NO	NO	30,000
Evans-Lacko et al. 2016 [37]	20	1280	0.05	25,600	27,298	2107	0.05	42,140	44,936	NO	NO	50,000
Eveleigh et al. 2014 [38]	21	−57	−0.02	2850	3039	− 1631	−0.02	70,180	75,790	NO	NO	80,000
Eveleigh et al. 2014 [38]	22	−97	− 0.03	3233	3448	1088	− 0.03	−36,267	−39,166	YES	NO	80,000
Fernandez et al. 2018 [39]	23	24	0.02	1194	1289	−16	0.02	− 819	− 884	YES	NO	30,000
Gensichen et al. 2013 [40]	24	989	0.02	38,429	44,579	− 1322	0.02	−66,092	−76,668	YES	NO	NA
Gerhards et al. 2010 [41]	25	− 484	−0.01	48,400	55,508	− 1787	− 0.01	178,700	204,943	NO	YES^c	80,000
Gerhards et al. 2010 [41]	26	−83	−0.01	8300	9519	−451	− 0.01	45,100	51,723	NO	NO	80,000
Goorden et al. 2015 [42]	27	1173	0.02	53,717	57,281	− 1131	0.02	−56,550	−60,301	YES	NO	80,000
Goorden et al. 2014 [43]	28	− 709	−0.05	14,589	16,346	− 2226	− 0.05	44,520	49,882	NO	NO	NA
Green et al. 2014 [44]	29	271	0.019	14,248	18,139	− 313	0.019	−16,465	−20,961	YES	NO	30,000
Green et al. 2014 [44]	30	316	0.051	6198	7875	− 1246	0.051	−24,434	−31,042	YES	NO	30,000
Groessl et al. 2018 [45]	31	− 2918	0.10	−29,180	−27,459	− 2598	0.10	−25,980	−24,448	NO	NO	50,000
Groessl et al. 2018 [45]	32	− 6087	0.17	−35,806	−33,694	− 5810	0.17	−34,176	−32,161	NO	NO	50,000
Hollinghurst et al. 2014 [46]	33	851	0.057	14,911	18,527	1039	0.057	18,228	22,649	NO	NO	30,000
Hollinghurst et al. 2010 [47]	34	−25	0.034	−17,173	− 29,240	− 330	0.034	− 9706	−16,526	NO	NO	30,000
Hornberger et al. 2015 [48]	35	− 3711	0.316	−11,744	− 9484	− 3764	0.316	−11,911	− 9619	NO	NO	50,000
Joling et al. 2013 [49]	36	75	0.04	1875	2101	4149	0.04	157,534	168,375	NO	YES	30,000
Joling et al. 2013 [49]	37	187	0.006	31,167	34,920	2631	0.006	438,299	491,086	NO	NO	30,000
Kessler et al. 2018 [50]	38	69	0.00935	7380	10,280	463	0.00935	49,572	69,052	NO	YES	20,000
Kolovos et al. 2016 [51]	39	−38	0.01	− 3800	− 4052	1579	0.01	157,900	168,375	YES	YES	30,000
Kuyken et al. 2015 [52]	40	124	−0.04	− 3103	− 4018	449	−0.04	−11,229	−14,618	NO	NO	NA
Maniadakis et al. 2013 [53]	41	350	0.026	13,682	14,776	14	0.026	547	613	NO	NO	50,000
	42	269	0.034	7959	8595	− 215	0.034	− 6324	− 7086	YES	NO
	43	154	0.015	10,591	11,438	−28	0.015	− 1867	− 2092	YES	NO
	44	273	0.03	9183	9917	−129	0.03	− 4300	− 4818	YES	NO
Meuldijk et al. 2015 [54]	45	1880	0.005	376,000	400,943	4795	0.005	959,000	1,022,619	NO	NO	33,600
Nordstrom et al. 2012 [55]	46	−16	0.00865	− 1831	− 2052	− 169	0.00865	−19,555	−21,910	NO	NO	33,600
Nordstrom et al. 2010 [56]	47	−41	0.025	− 1647	− 1846	−507	0.025	−20,264	−22,704	NO	NO	33,600
Nordstrom et al. 2010 [56]	48	−17	0.025	− 687	− 770	− 483	0.025	−19,308	−21,633	NO	NO	33,600
Nuijten et al. 2012 [57]	49	103	0.0062	16,363	18,116	−263	0.0062	−42,419	−46,963	YES	NO	80,000
Nuijten et al. 2012 [57]	50	126	0.0166	7553	8362	− 1992	0.0166	−120,000	−132,854	YES	NO	80,000
Patel et al. 2017 [58]	51	46	0.005	9333	7991	5	0.005	957	819	NO	NO	NA
Ramsberg et al. 2012 [59]	52	14	0.0036	3732	4181	−123	0.0036	−34,167	−38,282	YES	NO	NA
	53	−159	0.0045	−35,333	−39,589	− 327	0.0045	−72,667	−81,418	NO	NO
	54	−11	0.0052	− 2115	− 2370	− 206	0.0052	−39,615	−44,387	NO	NO
	55	−55	0.0072	− 7639	− 8559	− 325	0.0072	−45,139	−50,575	NO	NO
	56	−79	0.0086	− 9186	−10,292	− 404	0.0086	−46,977	−52,634	NO	NO
	57	− 147	0.0117	−12,564	−14,077	−588	0.0117	−50,256	− 56,309	NO	NO
	58	− 179	0.0131	−13,664	−15,310	− 673	0.0131	−51,374	−57,561	NO	NO
Richards et al. 2016 [60]	59	271	0.019	14,248	18,102	−313	0.019	−16,465	−20,918	YES	NO	20,000
Richards et al. 2017 [61]	60	− 343	0.05	− 6865	− 8661	− 2070	0.05	−41,392	−52,220	NO	NO	30,000
Romeo et al. 2013 [62]	61	693	0.03	23,100	28,702	705	0.03	23,500	28,842	NO	NO	30,000
	62	404	0.05	8080	10,040	−1106	0.05	−22,120	−27,149	YES	NO
	63	−289	0.02	−14,450	−17,954	−1811	0.02	−90,550	− 111,135	NO	NO
Romero-Sanchiz et al. 2017 [63]	64	−632	0.0567	−11,153	−11,743	− 644	0.0567	− 11,390	− 11,993	NO	NO	25,000
	65	− 466	0.0751	− 6204	− 6533	−479	0.0751	− 6381	− 6719	NO	NO
	66	−322	0.0793	− 4060	− 4274	− 409	0.0793	− 5160	− 5434	NO	NO
	67	− 295	0.0824	− 3576	− 3765	41	0.0824	497	523	YES	NO
Rubio-Valera et al. 2013 [64]	68	962	0.01	3592	4025	1866	0.01	9872	11,061	NO	NO	30,000
Sado et al. 2009 [65]	69	27,411	0.08	342,638	2887	− 693,858	0.08	−8,673,225	−73,089	YES	YES	30,000
Sado et al. 2009 [65]	70	27,411	0.03	913,700	7700	−693,858	0.03	−23,128,600	−194,904	YES	YES	30,000
Serrano-Blanco et al. 2009 [66]	71	71	−0.06	− 1180	− 1444	639	−0.06	−10,643	−13,020	NO	NO	NA
Simons et al. 2017 [67]	72	423	0.07	6043	6526	1141	0.07	16,300	17,603	NO	NO	80,000
Simons et al. 2017 [67]	73	1052	0.13	8092	8739	1741	0.13	13,392	14,463	NO	NO	80,000
Simpson et al. 2009 [68]	74	NA	NA	34,999	34,286	NA	NA	6667	6531	NO	NO	50,000
Simpson et al. 2009 [68]	75	NA	NA	− 1123	− 1100	NA	NA	− 7621	− 7466	NO	NO	50,000
Snedecor et al. 2010 [69]	76	174	0.0058	30,000	26,060	81	0.0058	13,881	12,058	NO	NO	50,000
Soini et al. 2017 [70]	77	−223	0.0134	−16,642	−17,523	− 1074	0.0134	−80,149	−84,392	NO	NO	NA
	78	−128	0.0166	− 7711	− 8119	− 957	0.0166	−57,651	−60,702	NO	NO
	79	−110	0.025	− 4400	− 4633	− 720	0.025	−28,800	−30,325	NO	NO
	80	−238	0.0276	− 8623	− 9080	− 1390	0.0276	−50,362	− 53,028	NO	NO
Stant et al. 2009 [71]	81	653	−0.21	− 3110	− 3727	1616	−0.21	− 7695	− 9222	NO	NO	NA
	82	1231	−0.16	− 7694	− 9220	1644	−0.16	−10,275	−12,314	NO	NO
	83	713	−0.04	−17,825	−21,362	1054	− 0.04	−26,350	−31,579	NO	NO
van der Aa et al. 2017 [72]	84	− 1154	0.03	−38,467	−41,019	− 877	0.03	−29,233	−31,172	NO	NO	30,000
van Eeden et al. 2015 [73]	85	1281	0.01	107,455	116,045	− 1913	0.01	−160,390	−173,211	YES	YES	40,000
Vasiliadis et al. 2017 [74]	86	− 1604	0.17	− 9435	− 7687	− 2590	0.17	−15,235	−12,412	NO	NO	NA
Vasiliadis et al. 2017 [74]	87	−1604	0.17	−9435	−7687	− 1904	0.17	−11,200	− 9125	NO	NO	NA
Vataire et al. 2014 [75]	88	− 243	0.078	− 3115	− 5056	− 1400	0.078	−17,949	−29,128	NO	NO	30,000
Warmerdam et al. 2010 [76]	89	455	0.01	45,500	52,182	256	0.01	22,609	25,929	NO	YES	30,000
Warmerdam et al. 2010 [76]	90	405	0.01	40,500	46,448	147	0.01	11,523	13,215	NO	YES	30,000
Weobong et al. 2017 [77]	91	−18	0.011	− 1721	− 1474	− 155	0.011	−14,438	−12,362	NO	NO	16,060
Wiles et al. 2014 [78]	92	850	0.057	14,911	19,138	814	0.053	15,358	17,237	NO	NO	30,000

^a changes in results regarding the cost-effectiveness quadrant (e.g. from cost-effective to dominant/dominated)
^b change in conclusions regarding the chosen threshold
^c not included in the results because the interpretation of the ICUR regarding the chosen threshold is inappropriate in this quadrant (negative incremental costs and QALYs)

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ISSN: 2191-1991

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