Table 3 Tobit and linear regression analyses of the relationship between health state utilities and patients’ characteristics

Intercept

1.092

0.101**

83.911

9.531**

74.268

8.717**

 0 months

ref

ref

ref

ref

ref

ref

 2 months

− 0.017

0.033

4.349

3.120

−0.270

2.847

 4 months

−0.001

0.039

1.538

3.699

1.773

3.347

 8 months

− 0.029

0.036

0.704

3.278

−4.164

2.961

 12 months

− 0.027

0.037

8.225

3.497*

−0.533

3.216

 16 months

0.004

0.040

6.400

3.714

6.568

3.384

 20 months

−0.009

0.045

1.183

4.180

2.669

3.894

 24 months

0.059

0.051

12.543

4.625**

7.240

4.268

Age

0.001

0.001

−0.079

0.102

0.070

0.092

Male

0.018

0.021

1.719

1.947

−1.069

1.791

BMI

0.001

0.002

0.200

0.207

0.127

0.197

 Colon

ref

ref

ref

ref

ref

ref

 Rectum

−0.006

0.021

0.189

1.916

0.201

1.750

Inoperable primary tumor

0.007

0.025

2.245

2.283

0.657

2.063

 0

ref

ref

ref

ref

ref

ref

 1

0.034

0.038

7.763

3.615*

−1.686

3.333

  ≥ 2

0.002

0.059

10.871

5.654

−5.621

5.151

 0

ref

ref

ref

ref

ref

ref

 1

−0.023

0.034

0.656

3.143

−1.168

2.894

 2

−0.043

0.038

0.080

3.519

0.225

3.231

  ≥ 3

−0.053

0.049

0.522

4.539

1.627

4.131

 First-line

ref

ref

ref

ref

ref

ref

 Break after first-line

−0.047

0.029

−4.536

2.657

0.399

2.418

 Second-line or later

−0.053

0.042

−11.939

4.000**

−1.377

3.725

 None

ref

ref

ref

ref

ref

ref

 EGFR

0.012

0.029

−2.900

2.699

0.766

2.468

 VEGF

0.022

0.025

−2.343

2.358

3.732

2.153

 Adiposity

−0.010

0.043

1.318

4.063

0.577

3.707

 Anemia

−0.055

0.045

−0.436

4.394

1.463

4.061

 Chronic gastric or bowel disease

−0.015

0.039

−7.434

3.742*

−4.851

3.378

 Coronary heart disease

0.022

0.039

−3.193

3.578

−4.569

3.235

 Heart failure

0.029

0.051

−1.782

4.688

−2.827

4.245

 Hypertension

−0.072

0.022**

−3.202

2.074

−2.377

1.904

 Moderate or severe kidney disease

−0.026

0.056

−0.262

5.268

1.763

5.082

 Diabetes mellitus^a

0.031

0.029

1.637

2.746

2.521

2.502

 Chronic pulmonary disease

−0.074

0.041

0.388

3.924

7.996

3.709**

 Thyroid disease

−0.041

0.036

1.108

3.385

1.788

3.108

 Tumor^b

0.010

0.036

4.215

3.435

−4.265

3.134

 Nausea and vomiting

0.000

0.001

−0.011

0.051

−0.058

0.047

 Fatigue

−0.004

0.000**

−0.384

0.044**

−0.472

0.040**

 Pain

−0.003

0.000**

−0.170

0.036**

−0.121

0.033**

σ

0.177

0.007**

–

–

–

–

Pseudo-R²

0.035

–

–

Adjusted R²

–

0.386

0.485