From: Mendelian randomization: estimation of inpatient hospital costs attributable to obesity
 | Covariate | Continuous BMI | Binary Obesity | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Coefficient | SE | P-value | 95% CI | Coefficient | SE | P-value | 95% CI | ||||
Low | High | Low | High | ||||||||
STAGE 1 | Weighted GRS | 0.825 | 0.013 | < 0.001 | 0.799 | 0.850 | 0.059 | 0.001 | < 0.001 | 0.056 | 0.061 |
Age | 0.289 | 0.012 | < 0.001 | 0.265 | 0.313 | 0.022 | 0.001 | < 0.001 | 0.019 | 0.024 | |
Age squared | −0.002 | 0.000 | < 0.001 | −0.002 | −0.002 | 0.000 | 0.000 | < 0.001 | 0.000 | 0.000 | |
Sex | 2.457 | 0.096 | < 0.001 | 2.270 | 2.644 | 0.076 | 0.009 | < 0.001 | 0.059 | 0.093 | |
Sex and Age Interaction | − 0.029 | 0.002 | < 0.001 | − 0.033 | − 0.026 | − 0.001 | 0.000 | < 0.001 | − 0.001 | −0.001 | |
Townsend Index | 0.145 | 0.002 | < 0.001 | 0.140 | 0.149 | 0.012 | 0.000 | < 0.001 | 0.012 | 0.013 | |
Current Smoker | −0.679 | 0.022 | < 0.001 | − 0.723 | − 0.635 | −0.041 | 0.002 | < 0.001 | −0.045 | − 0.037 | |
Black | 1.869 | 0.056 | < 0.001 | 1.759 | 1.978 | 0.128 | 0.005 | < 0.001 | 0.118 | 0.138 | |
Mixed | −0.008 | 0.096 | 0.934 | −0.196 | 0.180 | 0.001 | 0.009 | 0.891 | −0.016 | 0.018 | |
Asian | −0.630 | 0.046 | < 0.001 | −0.721 | −0.540 | − 0.050 | 0.004 | < 0.001 | − 0.058 | − 0.042 | |
Other | 0.352 | 0.062 | < 0.001 | 0.231 | 0.473 | 0.025 | 0.006 | < 0.001 | 0.013 | 0.036 | |
Intercept | 15.539 | 0.335 | < 0.001 | 14.883 | 16.195 | −0.577 | 0.030 | < 0.001 | − 0.637 | − 0.518 | |
STAGE 2 | BMI / Obesity | 14.363 | 7.170 | 0.045 | 0.310 | 28.415 | 201.579 | 100.644 | 0.045 | 4.322 | 398.837 |
Age | −47.242 | 5.869 | < 0.001 | −58.745 | −35.739 | −47.446 | 5.907 | < 0.001 | −59.023 | −35.868 | |
Age squared | 0.603 | 0.052 | < 0.001 | 0.502 | 0.705 | 0.607 | 0.053 | < 0.001 | 0.504 | 0.710 | |
Sex | − 626.552 | 46.813 | < 0.001 | −718.304 | −534.800 | −606.534 | 44.019 | < 0.001 | − 692.810 | − 520.258 | |
Sex and Age Interaction | 11.377 | 0.787 | < 0.001 | 9.834 | 12.920 | 11.151 | 0.765 | < 0.001 | 9.652 | 12.650 | |
Townsend Index | 10.027 | 1.461 | < 0.001 | 7.163 | 12.891 | 9.593 | 1.622 | < 0.001 | 6.414 | 12.773 | |
Smoking Status | 121.418 | 11.239 | < 0.001 | 99.389 | 143.446 | 119.860 | 10.928 | < 0.001 | 98.440 | 141.279 | |
Black | 116.296 | 27.979 | < 0.001 | 61.457 | 171.134 | 117.331 | 27.766 | < 0.001 | 62.910 | 171.751 | |
Mixed | 25.874 | 43.437 | 0.551 | −59.262 | 111.010 | 25.520 | 43.442 | 0.557 | −59.625 | 110.664 | |
Asian | 30.997 | 21.772 | 0.155 | −11.675 | 73.669 | 32.041 | 21.922 | 0.144 | −10.925 | 75.007 | |
Other | 32.182 | 28.098 | 0.252 | −22.890 | 87.254 | 32.291 | 28.100 | 0.25 | −22.784 | 87.366 | |
Intercept | 909.619 | 198.924 | < 0.001 | 519.735 | 1299.504 | 1249.149 | 155.737 | < 0.001 | 943.911 | 1554.387 | |
Model Fit | F-statistic | 3999 | 2453 | ||||||||
R2 | 0.031 | 0.017 | |||||||||
Partial R2 | 0.008 | 0.005 |