Mendelian randomization: estimation of inpatient hospital costs attributable to obesity

Dick, Katherine; Schneider, John E.; Briggs, Andrew; Lecomte, Pascal; Regnier, Stephane A.; Lean, Michael

doi:10.1186/s13561-021-00314-2

Health Economics Review

Table 3 Two-stage least squares regression results

From: Mendelian randomization: estimation of inpatient hospital costs attributable to obesity

	Covariate	Continuous BMI					Binary Obesity
		Coefficient	SE	P-value	95% CI		Coefficient	SE	P-value	95% CI
		Coefficient	SE	P-value	Low	High	Coefficient	SE	P-value	Low	High
STAGE 1	Weighted GRS	0.825	0.013	< 0.001	0.799	0.850	0.059	0.001	< 0.001	0.056	0.061
	Age	0.289	0.012	< 0.001	0.265	0.313	0.022	0.001	< 0.001	0.019	0.024
	Age squared	−0.002	0.000	< 0.001	−0.002	−0.002	0.000	0.000	< 0.001	0.000	0.000
	Sex	2.457	0.096	< 0.001	2.270	2.644	0.076	0.009	< 0.001	0.059	0.093
	Sex and Age Interaction	− 0.029	0.002	< 0.001	− 0.033	− 0.026	− 0.001	0.000	< 0.001	− 0.001	−0.001
	Townsend Index	0.145	0.002	< 0.001	0.140	0.149	0.012	0.000	< 0.001	0.012	0.013
	Current Smoker	−0.679	0.022	< 0.001	− 0.723	− 0.635	−0.041	0.002	< 0.001	−0.045	− 0.037
	Black	1.869	0.056	< 0.001	1.759	1.978	0.128	0.005	< 0.001	0.118	0.138
	Mixed	−0.008	0.096	0.934	−0.196	0.180	0.001	0.009	0.891	−0.016	0.018
	Asian	−0.630	0.046	< 0.001	−0.721	−0.540	− 0.050	0.004	< 0.001	− 0.058	− 0.042
	Other	0.352	0.062	< 0.001	0.231	0.473	0.025	0.006	< 0.001	0.013	0.036
	Intercept	15.539	0.335	< 0.001	14.883	16.195	−0.577	0.030	< 0.001	− 0.637	− 0.518
STAGE 2	BMI / Obesity	14.363	7.170	0.045	0.310	28.415	201.579	100.644	0.045	4.322	398.837
	Age	−47.242	5.869	< 0.001	−58.745	−35.739	−47.446	5.907	< 0.001	−59.023	−35.868
	Age squared	0.603	0.052	< 0.001	0.502	0.705	0.607	0.053	< 0.001	0.504	0.710
	Sex	− 626.552	46.813	< 0.001	−718.304	−534.800	−606.534	44.019	< 0.001	− 692.810	− 520.258
	Sex and Age Interaction	11.377	0.787	< 0.001	9.834	12.920	11.151	0.765	< 0.001	9.652	12.650
	Townsend Index	10.027	1.461	< 0.001	7.163	12.891	9.593	1.622	< 0.001	6.414	12.773
	Smoking Status	121.418	11.239	< 0.001	99.389	143.446	119.860	10.928	< 0.001	98.440	141.279
	Black	116.296	27.979	< 0.001	61.457	171.134	117.331	27.766	< 0.001	62.910	171.751
	Mixed	25.874	43.437	0.551	−59.262	111.010	25.520	43.442	0.557	−59.625	110.664
	Asian	30.997	21.772	0.155	−11.675	73.669	32.041	21.922	0.144	−10.925	75.007
	Other	32.182	28.098	0.252	−22.890	87.254	32.291	28.100	0.25	−22.784	87.366
	Intercept	909.619	198.924	< 0.001	519.735	1299.504	1249.149	155.737	< 0.001	943.911	1554.387
Model Fit	F-statistic	3999					2453
	R²	0.031					0.017
	Partial R²	0.008					0.005

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ISSN: 2191-1991

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