The addition of neoadjuvant pertuzumab for the treatment of HER2+ breast cancer: a cost estimate with real-world data

Borges, Andreia; Pereira, Filipa; Redondo, Patrícia; Antunes, Luís; Vieira, Cláudia; Antunes, Pedro; Bento, Maria José; Sousa, Susana; Lopes, José Machado; Rocha-Gonçalves, Francisco; de Sousa, Joaquim Abreu; Pereira, Deolinda Sousa; Borges, Marina

doi:10.1186/s13561-021-00332-0

Table 4 Costs of HER2-positive breast cancer treatment by regimen

From: The addition of neoadjuvant pertuzumab for the treatment of HER2+ breast cancer: a cost estimate with real-world data

	Doxorubicin, cyclophosphamide, docetaxel plus trastuzumab plus pertuzumab (n = 40)					Doxorubicin, cyclophosphamide, docetaxel, trastuzumab (n = 54)					P-value (average cost per patient)
	Total cost	Minimum cost per patient	Average cost per patient	Median cost per patient	Maximum cost per patient	Total cost	Minimum cost per patient	Average cost per patient	Median cost per patient	Maximum cost per patient	P-value (average cost per patient)
Chemotherapy/ Targeted therapy
Total cost of session of hospital day	1,697,525	21,501	42,438	42,187	73,656	1,515,163	9856	28,059	27,699	43,865	< 0.001
Drug cost for complete regimen	1,608,688	20,320	40,217	39,924	71,393	1,394,155	8971	25,818	25,394	41,406	< 0.001
Drug cost for neoadjuvant regimen	827,792	13,879	20,695	20,700	27,094	336,884	1654	6239	5846	10,614	< 0.001
Doxorubicin cost	1771	34	44	44	53	2446	35	45	45	60	0.266
Cyclophosphamide cost	2585	50	65	64	77	3567	51	66	65	92	0.327
Docetaxel cost	5330	109	133	128	171	7595	93	141	142	193	0.053
Pertuzumab cost	559,124	5855	13,978	14,637	17,564	–	–	–	–	–
Trastuzumab cost	258,982	4482	6475	6320	9820	323,276	1396	5987	5584	10,274	0.107
Drug cost for adjuvant regimen	780,896	2776	19,522	19,409	48,662	1,057,270	4469	19,949	19,544	35,818	0.691
Hormone therapy
Total cost for hormone therapy treatment^a	9857	6	352	28	1463	10,273	14	311	27	1781	0.780
Anastrozol cost	120	16	20	23	28	460	16	24	23	33	0.086
Exemestane cost	197	64	66	64	69	–	–	–	–	–
Goserelin cost	4005	320	501	521	641	4966	721	828	801	961	< 0.001
Tamoxifen cost	518	21	27	28	35	420	12	26	28	35	0.576
Radiotherapy
Total radiotherapy costs	200,979	3199	5153	4955	8029	225,626	105	4339	4098	7528	0.006
Complex technique cost	162,094	1004	4156	4015	8029	151,305	1004	3690	3011	7528	0.269
Simple technique cost	38,885	209	1341	1359	2509	74,321	105	1689	1672	2927	0.041
Hospital appointments and Exams
Total cost of hospital attendances	190,415	3000	4760	4848	7564	242,298	2683	4487	4521	6744	0.175
Inpatient care
Total hospitalizations costs	106,941	1467	2674	1992	7589	154,175	1007	2855	1992	10,877	0.617
Hospitalizations cost for breast cancer surgery	81,638	1467	2041	1992	2692	113,054	944	2094	1589	7011	0.801
Mastectomy cost	63,429	1467	2114	1992	2692	99,899	1331	2220	1992	7011	0.679
Conservative treatment cost	18,208	1748	1821	1748	1992	13,155	944	1462	1454	1992	0.010
Outpatient care
Total outpatient costs^c	49,274	289	1263	289	18,544	33,710	162	648	289	5235	0.219
Total cost	2,254,991	27,487	56,375	54,819	89,543	2,181,245	15,089	40,393	40,797	60,427	< 0.001

All Values in the table are expressed in Euros - €
^aIncludes drugs consumed from outpatient pharmacy and sessions of hospital day. ^bIncludes scheduled consultations, emergency appointments and complementary diagnostic and treatment exams. ^cIncludes surgical outpatient care and IPO Porto homestay costs

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ISSN: 2191-1991

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