Table 1 Summary of inputs and data sources used
Treatment | Vaborem | BAT | Comments and sources |
|---|---|---|---|
Efficacy | |||
Cure | 59.4%. | 26.7% | TANGO II [15] |
Mortality at day 28 | 15.6% | 33.3% | TANGO II [15] |
Probability of discharge | |||
At home | 77.3% | 77.3% | |
For long-term care | 22.7% | 22.7% | |
Probability of complication | |||
Septic shock | 3.1% | 26.7% | |
Nephrotoxicity | 3.1% | 26.7% | |
RRT (inpatient) | 25.0% | 25.0% | Italian medical expert opinion. Applied to patients with nephrotoxicity |
RRT (after discharge) | 40.0% | 40.0% | Italian medical expert opinion. Applied to patients who have received RRT even during admission. |
Mortality for all causes (after 28 days)– Without Chronic RRT | |||
Year 1 | 29.6% | 29.6% | Calculated considering: • Patients’ characteristics from TANGO II (sex and age) [15] • Italian mortality tables [20] • Proportion of patients with low (1–2), medium (3–4) and high (≥5) CCI of 10.6, 10.6 and 78.7%, respectively (TANGO II) [15] • HR as per CCI level [21] |
Year 2 | 30.3% | 30.3% | |
Year 3 | 31.0% | 31.0% | |
Year 4 | 31.8% | 31.8% | |
Year 5 | 32.6% | 32.6% | |
Mortality for all causes (after 28 days)– With Chronic RRT | |||
Year 1 | 61.4% | 61.4% | Calculated considering: • Patients’ characteristics from TANGO II (sex and age) [15] • Italian mortality tables [20] • Proportion of patients with low (1–2), medium (3–4) and high (≥5) CCI of 10.6, 10.6 and 78.7%, respectively (TANGO II) [15] • Scottish register of RRT patients [22] |
Year 2 | 70.3% | 70.3% | |
Year 3 | 75.4% | 75.4% | |
Year 4 | 89.2% | 89.2% | |
Year 5 | 92.4% | 92.4% | |