Table 1 Clinical Input Parameters
Model Input | Base-Case Value | Range for Sensitivity Analysis | Reference |
|---|---|---|---|
Initial Probabilities | |||
For each health state mRS 0–6 among EVT-treated patients | 90-day mRS distribution for different times to EVT | Adjusted by distribution according to sample size | |
For each health state mRS 0–6 among EVT-ineligible patients | 90-day mRS distribution of ASPECTS 0–5 control arm | Adjusted by distribution according to sample size | |
EVT Eligibility by Time | |||
61–120 min | 1 | 0.90–1.00 | Boulouis et al. [13] and expert consensus |
121–180 min | 0.94 | 0.84–1.00 | |
181–240 min | 0.88 | 0.78–0.98 | |
241–300 min | 0.82 | 0.72–0.92 | |
301–360 min | 0.76 | 0.66–0.86 | |
IVT Eligibility | |||
EVT Patients | 0.83 | 0.82–084 | HERMES Data [2] |
Non-EVT Patients | 0.88 | 0.87–0.89 | |
Transition Probabilities | |||
Recurrent stroke rate | Time-dependent values | 0.044–0.082 | Pennlert et al. [14] |
Annual death rate of population | Age-dependent values | N/A | China Life Table [15] |
Death hazard ratio by mRS, relative to general age-matched population | |||
mRS 0 | 1.54 | 1.21–1.84 | Hong et al. [16] |
mRS 1 | 1.54 | 1.21–1.84 | |
mRS 2 | 2.18 | 1.58–1.69 | |
mRS 3 | 3.18 | 1.58–1.69 | |
mRS 4 | 4.56 | 2.37–3.03 | |
mRS 5 | 6.56 | 3.83–6.44 | |
mRS Distribution | |||
mRS after recurrent stroke | 90-day mRS distribution of HERMES control arm | Adjusted by distribution according to sample size | |