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Table 5 Articles about global cost related to stroke

From: The costs associated with stroke care continuum: a systematic review

First Author

Year of publication

Country

Objectives

Methods

Results

Design and

GRADE LEVEL[32]

Participants

Instruments

Calculated stroke costs

Alvarez-Sabin, 2013 (Spain) [44]

To find the cost of stroke in Spain

Epidemiological, observational, prospective, multicenter study

2 + GRADE

321 patients

Sociodemographic, clinical, and economic data

Direct costs

Indirect costs

Total average cost per patient/year was €27,711. Direct healthcare costs €849 patient/year and non-healthcare costs to an average of €18,643patient/year. Productivity loss costs per patient/year were €276

Van Eeden, 2015 (Netherlands) [45]

Explore over 1 year poststroke the societal costs, changes in costs and quality of life (QoL) and the relation between costs and QoL

Epidemiological, observational, prospective, multicenter study

2 + GRADE

395 patients

Cost-of-illness (in Euros) and QoL (in utilities) of a disease

Direct costs

Indirect costs

Indirect cost = €11,416

Direct cost = €18,068

Total societal costs for 1 year

poststroke were €29 484

Xu, 2018

(UK), [46]

To estimate patient-level health and social care costs of stroke for all patients admitted to hospital with stroke in UK

Epidemiological, observational

Retrospective

Health economic simulation

2 + GRADE

111,846 patients

Health Care Costs

Productivity Costs

Direct costs

Indirect costs

The estimated stroke cost varied widely according to patient characteristics, ranging from €8149 to €49,922 at one year and €21,259 to €119,464 at five years

Benjamin. 2019

(EEUU) [4]

To estimate the cost of Cardio Vascular Diseases and risk factors

Statistical update

2 + GRADE

18,462 patients

Health interview surveys

Direct costs

Indirect costs

Direct care €6673 /patient/year

Post ictus Care €9412/patient/year

Luengo-Fernandez. 2020

(UK) [2]

To provide an estimate of the overall economic costs of stroke for all 28 countries of the EU

Population-based cost analysis

2 + GRADE

1,5 million patients

32 European countries

Population-based cost analysis

Direct costs

Indirect costs

Health Care: €17,728 /patient/year

Social Care: €3165/patient/year

Productivity costs: €8336/ patient/year

Informal care costs: €10,508/ patient/year

Total costs: €39,736,66 /patient/year

Patel A, 2020

(UK) [47]

To estimate 2014/2015 annual cost from a societal perspective

Epidemiological retrospective

study

2 + GRADE

331 patients

Annual mean cost per person and aggregate UK cost of stroke for individuals aged ≥ 40

Health and social costs

Direct costs

Indirect costs

Mean cost of new-onset stroke is €61,665 (95% CI €57,109-€66,220) in the first year after stroke and €33,648 (€27,477-€39,819) in subsequent years

Rochmah TN, 2021

Indonesia [48]

To analyze the burden of stroke: analyzing the average length of hospitalization, and the magnitude of economic losses due to stroke

Systematic review

1 + GRADE

13 articles

Cost of illness studies that assess burden of stroke in primary and referral healthcare (hospital-based)

Direct and indirect costs

Direct costs

Indirect costs

The economic burden of stroke disease based on cost of illness method, which is approximately equal to € 1478- €265,613 (direct costs 86.2%, and indirect costs 13.8%)

Stefan Strilciuc, 2021 Romania[49]

To compile the results of existing studies on the economic burden of stroke,

Systematic review

1 + GRADE

forty-six articles published in twenty-three countries between 1994 and 2019

Across all cost perspectives

Overall costs

Costs in the per patient per year category varied from €103,578 in South Korea (for hemorrhagic stroke) to €610 in Singapore